AK8

Entrez Summary: N/A
UniProt Summary: Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000269|PubMed:21080915, ECO:0000269|PubMed:23416111}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
BML-284 0.09μM R08 exp460	1.75
All-trans-Retinoic-Acid 8μM R07 exp333	1.81

cytidylate kinase activity
adenylate kinase activity
nucleoside monophosphate phosphorylation
nucleoside diphosphate kinase activity
ventricular system development
nucleobase-containing small molecule interconversion
sperm flagellum
nucleoside diphosphate phosphorylation
nucleotide phosphorylation
nucleoside triphosphate biosynthetic process
nucleoside monophosphate metabolic process
nucleoside diphosphate metabolic process
nucleoside triphosphate metabolic process
axoneme
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
nucleotide metabolic process
nucleoside phosphate metabolic process
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
brain development
head development
organophosphate metabolic process
central nervous system development
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
phosphorylation
organic cyclic compound biosynthetic process
ATP binding
cellular nitrogen compound biosynthetic process
small molecule metabolic process