ALOX5

Entrez Summary: This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
UniProt Summary: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. {ECO:0000269|PubMed:21233389}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Lipoxygenase
PLAT

arachidonate 5-lipoxygenase activity
arachidonic acid metabolite production involved in inflammatory response
leukotriene production involved in inflammatory response
lipoxin metabolic process
lipoxin biosynthetic process
cellular response to interleukin-18
interleukin-18-mediated signaling pathway
nuclear envelope lumen
response to interleukin-18
production of molecular mediator involved in inflammatory response
lipoxygenase pathway
leukotriene biosynthetic process
long-chain fatty acid biosynthetic process
leukotriene metabolic process
unsaturated fatty acid biosynthetic process
icosanoid biosynthetic process
fatty acid derivative biosynthetic process
unsaturated fatty acid metabolic process
nuclear matrix
icosanoid metabolic process
long-chain fatty acid metabolic process
secretory granule lumen
fatty acid biosynthetic process
ficolin-1-rich granule lumen
iron ion binding
fatty acid derivative metabolic process
nuclear envelope
monocarboxylic acid biosynthetic process
nuclear membrane
carboxylic acid biosynthetic process
organic acid biosynthetic process
fatty acid metabolic process
neutrophil degranulation
neutrophil activation involved in immune response
inflammatory response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity