ALX3

Entrez Summary: This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblastoma tumors. [provided by RefSeq, Jul 2008].
UniProt Summary: Transcriptional regulator with a possible role in patterning of mesoderm during development. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
CVT-10216 0.1μM R06 exp278	-1.82
Daidzin 10μM R06 exp280	-1.77

embryonic hindlimb morphogenesis
embryonic forelimb morphogenesis
hindlimb morphogenesis
forelimb morphogenesis
embryonic cranial skeleton morphogenesis
cranial skeletal system development
embryonic skeletal system morphogenesis
embryonic appendage morphogenesis
embryonic limb morphogenesis
embryonic skeletal system development
appendage morphogenesis
limb morphogenesis
limb development
appendage development
skeletal system morphogenesis
embryonic organ morphogenesis
RNA polymerase II regulatory region sequence-specific DNA binding
embryonic organ development
pattern specification process
skeletal system development
embryonic morphogenesis
chordate embryonic development
embryo development ending in birth or egg hatching
animal organ morphogenesis
embryo development
regulation of apoptotic process
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of programmed cell death
regulation of cell death