AMDHD2

Entrez Summary: N/A
UniProt Summary: Hydrolyzes the N-glycolyl group from N- glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N- glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. {ECO:0000269|PubMed:22692205}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Amidohydro 3
Amidohydro 1

N-acetylglucosamine-6-phosphate deacetylase activity
N-acetylgalactosamine-6-phosphate deacetylase activity
N-acetylglucosamine catabolic process
N-acetylneuraminate catabolic process
glucosamine-containing compound catabolic process
UDP-N-acetylglucosamine biosynthetic process
N-acetylneuraminate metabolic process
amino sugar catabolic process
amino sugar biosynthetic process
UDP-N-acetylglucosamine metabolic process
N-acetylglucosamine metabolic process
nucleotide-sugar biosynthetic process
glucosamine-containing compound metabolic process
nucleotide-sugar metabolic process
amino sugar metabolic process
antibiotic catabolic process
antibiotic metabolic process
drug catabolic process
carbohydrate derivative catabolic process
carboxylic acid catabolic process
organic acid catabolic process
small molecule catabolic process
carbohydrate metabolic process
drug metabolic process
nucleobase-containing small molecule metabolic process
carbohydrate derivative biosynthetic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cellular nitrogen compound biosynthetic process
small molecule metabolic process
organic substance catabolic process
cellular catabolic process