AMHR2

Entrez Summary: This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2009].
UniProt Summary: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
SNS-032 15μM R08 exp443	-1.8
Vinblastine 0.2μM R03 exp108	-1.71
Fas-L 44ng/ml R08 exp482	1.92
Epigallocatechin gallate 20μM R05 exp230	2.39

Pkinase
Pkinase Tyr

anti-Mullerian hormone signaling pathway
anti-Mullerian hormone receptor activity
Mullerian duct regression
transforming growth factor beta receptor activity, type II
anatomical structure regression
hormone binding
transforming growth factor beta-activated receptor activity
growth factor binding
SMAD binding
female gonad development
BMP signaling pathway
development of primary female sexual characteristics
transforming growth factor beta receptor signaling pathway
cellular response to BMP stimulus
response to BMP
female sex differentiation
male gonad development
development of primary male sexual characteristics
cellular response to transforming growth factor beta stimulus
male sex differentiation
response to transforming growth factor beta
transmembrane receptor protein serine/threonine kinase signaling pathway
receptor complex
gonad development
development of primary sexual characteristics
sex differentiation
reproductive structure development
reproductive system development
pattern specification process
cellular response to growth factor stimulus
response to growth factor
developmental process involved in reproduction
enzyme linked receptor protein signaling pathway
protein phosphorylation
cellular response to endogenous stimulus
phosphorylation
integral component of plasma membrane
reproductive process
reproduction
response to endogenous stimulus