AMIGO2

Entrez Summary: N/A
UniProt Summary: Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
positive regulation of synapse assembly
regulation of synapse assembly
homophilic cell adhesion via plasma membrane adhesion molecules
regulation of synapse organization
regulation of synapse structure or activity
cell-cell adhesion via plasma-membrane adhesion molecules
cell-cell adhesion
positive regulation of cellular component biogenesis
positive regulation of nervous system development
brain development
head development
negative regulation of apoptotic process
negative regulation of programmed cell death
regulation of nervous system development
cell adhesion
biological adhesion
regulation of cellular component biogenesis
central nervous system development
negative regulation of cell death
positive regulation of cellular component organization
positive regulation of developmental process
regulation of apoptotic process
regulation of programmed cell death
regulation of cell death
positive regulation of multicellular organismal process