AMPD1

Entrez Summary: Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythocyte-specific isoforms, respectively. Deficiency of the muscle-specific enzyme is apparently a common cause of exercise-induced myopathy and probably the most common cause of metabolic myopathy in the human. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010].
UniProt Summary: AMP deaminase plays a critical role in energy metabolism.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

AMP deaminase activity
IMP salvage
purine nucleotide salvage
myosin heavy chain binding
IMP biosynthetic process
IMP metabolic process
AMP metabolic process
nucleotide salvage
purine-containing compound salvage
purine ribonucleoside monophosphate biosynthetic process
purine nucleoside monophosphate biosynthetic process
ribonucleoside monophosphate biosynthetic process
cellular metabolic compound salvage
purine ribonucleoside monophosphate metabolic process
purine nucleoside monophosphate metabolic process
nucleoside monophosphate biosynthetic process
ribonucleoside monophosphate metabolic process
nucleoside monophosphate metabolic process
purine ribonucleotide biosynthetic process
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
drug metabolic process
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
carbohydrate derivative biosynthetic process
organophosphate metabolic process
carbohydrate derivative metabolic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process