ANGPT4
Gene Information
- Official Symbol: ANGPT4
- Official Name: angiopoietin 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 51378
- UniProt: Q9Y264
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis. {ECO:0000269|PubMed:15284220}.
Pfam Domains GO Terms
Pfam Domains
| Fibrinogen C |
GO Terms
| transmembrane receptor protein tyrosine kinase activator activity |
| activation of transmembrane receptor protein tyrosine kinase activity |
| endothelial cell proliferation |
| negative regulation of blood vessel endothelial cell migration |
| negative regulation of endothelial cell migration |
| positive regulation of blood vessel endothelial cell migration |
| receptor tyrosine kinase binding |
| negative regulation of epithelial cell migration |
| epithelial cell proliferation |
| regulation of blood vessel endothelial cell migration |
| positive regulation of endothelial cell migration |
| negative regulation of angiogenesis |
| negative regulation of blood vessel morphogenesis |
| negative regulation of vasculature development |
| Notch signaling pathway |
| positive regulation of epithelial cell migration |
| regulation of endothelial cell migration |
| positive regulation of angiogenesis |
| positive regulation of vasculature development |
| cellular response to hypoxia |
| positive regulation of peptidyl-tyrosine phosphorylation |
| cellular response to decreased oxygen levels |
| cellular response to oxygen levels |
| regulation of epithelial cell migration |
| regulation of peptidyl-tyrosine phosphorylation |
| negative regulation of cell migration |
| negative regulation of cell motility |
| regulation of angiogenesis |
| negative regulation of cellular component movement |
| angiogenesis |
| regulation of vasculature development |
| negative regulation of locomotion |
| activation of protein kinase activity |
| response to hypoxia |
| response to decreased oxygen levels |
| leukocyte migration |
| response to oxygen levels |
| blood vessel morphogenesis |
| blood vessel development |
| positive regulation of cell migration |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| vasculature development |
| cardiovascular system development |
| positive regulation of cell motility |
| positive regulation of protein kinase activity |
| positive regulation of cellular component movement |
| positive regulation of locomotion |
| cell population proliferation |
| positive regulation of kinase activity |
| tube morphogenesis |
| positive regulation of transferase activity |
| enzyme linked receptor protein signaling pathway |
| regulation of protein kinase activity |
| cellular protein-containing complex assembly |
| tube development |
| regulation of cell migration |
| circulatory system development |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| regulation of cell motility |
| negative regulation of developmental process |
| cell migration |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of cellular component movement |
| negative regulation of cell death |
| positive regulation of protein phosphorylation |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cell motility |
| localization of cell |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| response to abiotic stimulus |
| negative regulation of multicellular organismal process |
| positive regulation of protein modification process |
| locomotion |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| protein-containing complex assembly |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell death |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| KU-0063794 3.8μM R02 exp71 | -1.7 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13396
- Expression level (log2 read counts): 1.53
Expression Distribution
ANGPT4 Expression in NALM6 Cells: 1.53
