ANKFY1

Entrez Summary: N/A
UniProt Summary: Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1- dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport. {ECO:0000269|PubMed:15328530, ECO:0000269|PubMed:22284051, ECO:0000269|PubMed:24102721}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Tanespimycin 14μM R08 exp527	-2.3
BI-6727 0.001μM R01 exp42	-1.84
Citral 75μM R06 exp275	-1.8
NN-Dimethylsphingosine 2.5μM R08 exp508	1.77

positive regulation of pinocytosis
Golgi to lysosome transport
macropinosome
endosomal vesicle fusion
regulation of pinocytosis
phosphatidylinositol phosphate binding
Golgi to vacuole transport
retromer complex
vesicle fusion
organelle membrane fusion
retrograde transport, endosome to Golgi
organelle fusion
positive regulation of endocytosis
post-Golgi vesicle-mediated transport
lysosomal transport
membrane fusion
vacuolar transport
cytosolic transport
Rab GTPase binding
regulation of endocytosis
endosome membrane
endosomal transport
early endosome
endosome
lysosomal membrane
vesicle organization
Golgi vesicle transport
regulation of vesicle-mediated transport
endocytosis
import into cell
intracellular membrane-bounded organelle
membrane organization
positive regulation of transport
positive regulation of cellular component organization
intracellular transport
establishment of localization in cell
regulation of transport
vesicle-mediated transport
membrane