APOBEC3G

Gene Information

Official Symbol: APOBEC3G
Official Name: apolipoprotein B mRNA editing enzyme catalytic subunit 3G
Aliases and Previous Symbols: N/A
Entrez ID: 60489
UniProt: Q9HC16
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV). May inhibit the mobility of LTR and non-LTR retrotransposons. {ECO:0000269|PubMed:12167863, ECO:0000269|PubMed:12808465, ECO:0000269|PubMed:12808466, ECO:0000269|PubMed:12809610, ECO:0000269|PubMed:12859895, ECO:0000269|PubMed:12970355, ECO:0000269|PubMed:14528300, ECO:0000269|PubMed:14557625, ECO:0000269|PubMed:15031497, ECO:0000269|PubMed:16378963, ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:18288108, ECO:0000269|PubMed:19458006, ECO:0000269|PubMed:20219927, ECO:0000269|PubMed:20335265, ECO:0000269|PubMed:21123384, ECO:0000269|PubMed:21835787, ECO:0000269|PubMed:22791714, ECO:0000269|PubMed:22807680, ECO:0000269|PubMed:22915799, ECO:0000269|PubMed:23097438, ECO:0000269|PubMed:23152537}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7924
Expression level (log2 read counts): 6.79

Expression Distribution

Screen	Score
Etoposide 1μM R00 exp19	-1.88
Cyclosporin-A 0.8μM R07 exp347	1.94

APOBEC C
APOBEC N

apolipoprotein B mRNA editing enzyme complex
deoxycytidine deaminase activity
DNA cytosine deamination
cytidine catabolic process
cytidine metabolic process
cytidine deamination
cytidine to uridine editing
cytidine deaminase activity
pyrimidine ribonucleoside catabolic process
DNA deamination
pyrimidine ribonucleoside metabolic process
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
regulation of single stranded viral RNA replication via double stranded DNA intermediate
DNA demethylation
base conversion or substitution editing
ribonucleoside catabolic process
regulation of transposition
negative regulation of transposition
pyrimidine nucleoside catabolic process
DNA dealkylation
positive regulation of defense response to virus by host
nucleoside catabolic process
pyrimidine nucleoside metabolic process
regulation of defense response to virus by host
pyrimidine-containing compound catabolic process
glycosyl compound catabolic process
nucleobase-containing small molecule catabolic process
negative regulation of viral genome replication
demethylation
DNA methylation or demethylation
regulation of defense response to virus
ribonucleoside metabolic process
negative regulation of viral life cycle
P-body
DNA modification
regulation of viral genome replication
negative regulation of viral process
pyrimidine-containing compound metabolic process
nucleoside metabolic process
glycosyl compound metabolic process