APOL1

Entrez Summary: This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

intrinsic component of membrane
very-low-density lipoprotein particle
high-density lipoprotein particle
cytolysis
killing of cells of other organism
disruption of cells of other organism
chloride channel activity
chloride transmembrane transport
cell killing
chloride transport
inorganic anion transmembrane transport
cholesterol metabolic process
lipoprotein metabolic process
secondary alcohol metabolic process
sterol metabolic process
blood microparticle
lipid binding
modification of morphology or physiology of other organism
inorganic anion transport
receptor-mediated endocytosis
steroid metabolic process
anion transmembrane transport
lipid transport
endoplasmic reticulum lumen
alcohol metabolic process
lipid localization
post-translational protein modification
organic hydroxy compound metabolic process
endocytosis
anion transport
inorganic ion transmembrane transport
import into cell
innate immune response
interspecies interaction between organisms
ion transmembrane transport
defense response to other organism
lipid metabolic process
transmembrane transport
response to other organism
response to external biotic stimulus