AQP8

Entrez Summary: N/A
UniProt Summary: Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
UNC1999 2μM R03 exp155	1.89
Ribavirin 10μM R01 exp52	1.91

water channel activity
water transport
fluid transport
cellular response to cAMP
apical part of cell
response to cAMP
mitochondrial membrane
response to organophosphorus
response to purine-containing compound
cellular response to organic cyclic compound
cellular response to organonitrogen compound
cellular response to nitrogen compound
response to organic cyclic compound
response to organonitrogen compound
cellular response to oxygen-containing compound
response to nitrogen compound
cellular response to endogenous stimulus
transmembrane transport
integral component of plasma membrane
response to endogenous stimulus
response to oxygen-containing compound