ARHGAP1

Entrez Summary: N/A
UniProt Summary: GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Mubritinib 0.2μM R02 exp65	-2
Rapamycin 0.001μM R08 exp429	-1.95
PFI-2 4μM R05 exp239	1.9
Lead acetate 2000μM R08 exp498 no dilution day6	2.09

CRAL TRIO
RhoGAP

negative regulation of endocytic recycling
sorting endosome
regulation of endocytic recycling
transferrin transport
SH3/SH2 adaptor activity
negative regulation of intracellular transport
iron ion transport
Rho protein signal transduction
transition metal ion transport
SH3 domain binding
Rab GTPase binding
endosome membrane
endosomal transport
Ras protein signal transduction
GTPase activator activity
cadherin binding
small GTPase mediated signal transduction
regulation of small GTPase mediated signal transduction
regulation of intracellular transport
positive regulation of GTPase activity
regulation of GTPase activity
negative regulation of transport
regulation of vesicle-mediated transport
metal ion transport
perinuclear region of cytoplasm
positive regulation of hydrolase activity
cation transport
regulation of cellular localization
regulation of hydrolase activity
ion transport
positive regulation of catalytic activity
protein transport
intracellular transport
peptide transport
amide transport
establishment of protein localization
positive regulation of signal transduction
intracellular signal transduction
positive regulation of molecular function
positive regulation of cell communication