ARHGAP12

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
UM0011500 5μM R05 exp245	-1.87
GSK626616 14μM R08 exp485	2.1

RhoGAP
PH

phagocytic cup
morphogenesis of an epithelial sheet
negative regulation of small GTPase mediated signal transduction
phagocytosis, engulfment
plasma membrane invagination
membrane invagination
actin filament organization
GTPase activator activity
phagocytosis
regulation of small GTPase mediated signal transduction
positive regulation of GTPase activity
morphogenesis of an epithelium
supramolecular fiber organization
regulation of GTPase activity
actin cytoskeleton organization
negative regulation of intracellular signal transduction
endocytosis
tissue morphogenesis
actin filament-based process
import into cell
positive regulation of hydrolase activity
membrane organization
cytoskeleton organization
epithelium development
negative regulation of signal transduction
regulation of hydrolase activity
negative regulation of cell communication
negative regulation of signaling
positive regulation of catalytic activity
negative regulation of response to stimulus
tissue development
positive regulation of molecular function
regulation of intracellular signal transduction
vesicle-mediated transport