ARHGEF11

Gene Information

Official Symbol: ARHGEF11
Official Name: Rho guanine nucleotide exchange factor 11
Aliases and Previous Symbols: N/A
Entrez ID: 9826
UniProt: O15085
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4961
Expression level (log2 read counts): 2.93

Expression Distribution

RGS-like
RhoGEF
RGS
PDZ

G protein-coupled receptor binding
Rho guanyl-nucleotide exchange factor activity
Rho protein signal transduction
striated muscle contraction
establishment of cell polarity
regulation of Rho protein signal transduction
establishment or maintenance of cell polarity
regulation of Ras protein signal transduction
Ras protein signal transduction
muscle contraction
GTPase activator activity
muscle system process
small GTPase mediated signal transduction
regulation of small GTPase mediated signal transduction
positive regulation of GTPase activity
regulation of cell growth
regulation of GTPase activity
actin cytoskeleton organization
actin filament-based process
positive regulation of apoptotic process
positive regulation of programmed cell death
regulation of growth
positive regulation of cell death
positive regulation of hydrolase activity
cytoskeleton organization
regulation of hydrolase activity
G protein-coupled receptor signaling pathway
positive regulation of catalytic activity
positive regulation of transcription, DNA-templated
regulation of apoptotic process
regulation of programmed cell death
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
regulation of cell death
intracellular signal transduction
positive regulation of RNA metabolic process
positive regulation of molecular function
regulation of intracellular signal transduction
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process