ARHGEF15

Gene Information

Official Symbol: ARHGEF15
Official Name: Rho guanine nucleotide exchange factor 15
Aliases and Previous Symbols: N/A
Entrez ID: 22899
UniProt: O94989
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene. [provided by RefSeq, Aug 2010].
UniProt Summary: Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. {ECO:0000269|PubMed:12775584}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2047
Expression level (log2 read counts): 0.02

Expression Distribution

Screen	Score
Atovaquone 15μM R08 exp451	-1.82
Ammonium tetrathiomolybdate 10μM R08 exp448	-1.74
LY2090314 0.003μM R08 exp500 no dilution day6	1.85

Gene	Correlation
CCDC64B	0.424
MEPCE	0.423
SF3A1	0.423
POLR2F	0.412
CHD4	0.412
RPS2	0.403
NAPA	0.402
TCEB3CL2	0.402

negative regulation of synapse maturation
retina vasculature morphogenesis in camera-type eye
regulation of synapse maturation
retina vasculature development in camera-type eye
negative regulation of synapse organization
positive regulation of stress fiber assembly
positive regulation of actin filament bundle assembly
Rho guanyl-nucleotide exchange factor activity
regulation of stress fiber assembly
regulation of actomyosin structure organization
regulation of actin filament bundle assembly
retina development in camera-type eye
regulation of Rho protein signal transduction
positive regulation of supramolecular fiber organization
regulation of synapse organization
positive regulation of cytoskeleton organization
regulation of synapse structure or activity
regulation of Ras protein signal transduction
regulation of actin filament organization
GTPase activator activity
negative regulation of nervous system development
camera-type eye development
regulation of actin cytoskeleton organization
regulation of small GTPase mediated signal transduction
regulation of supramolecular fiber organization
eye development
visual system development
sensory system development
regulation of actin filament-based process
positive regulation of GTPase activity
dendrite
regulation of GTPase activity
vasculature development
cardiovascular system development
positive regulation of cellular component biogenesis
regulation of cytoskeleton organization
sensory organ development
positive regulation of organelle organization
negative regulation of cellular component organization
positive regulation of hydrolase activity