ARHGEF18

Entrez Summary: Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008].
UniProt Summary: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). {ECO:0000269|PubMed:11085924, ECO:0000269|PubMed:14512443, ECO:0000269|PubMed:15558029, ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:28132693}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Golgicide-A 4μM R03 exp122	-1.85
Benzoate 20000μM R08 exp456	-1.74

PH
RhoGEF

Rho guanyl-nucleotide exchange factor activity
apical part of cell
transforming growth factor beta receptor signaling pathway
guanyl-nucleotide exchange factor activity
regulation of Rho protein signal transduction
regulation of cell shape
cellular response to transforming growth factor beta stimulus
response to transforming growth factor beta
nucleic acid binding
transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of Ras protein signal transduction
apical plasma membrane
small GTPase mediated signal transduction
regulation of small GTPase mediated signal transduction
cytoskeleton
regulation of cell morphogenesis
actin cytoskeleton organization
cellular response to growth factor stimulus
response to growth factor
cell junction
actin filament-based process
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
enzyme linked receptor protein signaling pathway
regulation of anatomical structure morphogenesis
cytoskeleton organization
cellular response to endogenous stimulus
G protein-coupled receptor signaling pathway
response to endogenous stimulus
regulation of apoptotic process
regulation of programmed cell death
regulation of cell death
intracellular signal transduction
regulation of intracellular signal transduction