ARMC4
Gene Information
- Official Symbol: ARMC4
- Official Name: armadillo repeat containing 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 55130
- UniProt: Q5T2S8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: N/A
Function Summary
- Entrez Summary: The protein encoded by this gene contains ten Armadillo repeat motifs (ARMs) and one HEAT repeat, and is thought to be involved in ciliary and flagellar movement. This protein has been shown to localize to the ciliary axonemes and at the ciliary base of respiratory cells. Studies indicate that mutations in this gene cause partial outer dynein arm (ODA) defects in respiratory cilia. The cilia of cells with mutations in this gene displayed either reduced ciliary beat frequency and amplitude, or, complete immotility. Some individuals with primary ciliary dyskensia (PCD) have been shown to have mutations in this gene. PCD is characterized by chronic airway disease and left/right body asymmetry defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015].
- UniProt Summary: Ciliary protein that may be involved in a late step of axonemal outer dynein arm assembly. {ECO:0000269|PubMed:23849778}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 9687
- Expression level (log2 read counts): 0.58
ARMC4 Expression in NALM6 Cells: 0.58
