ARRDC4

Entrez Summary: N/A
UniProt Summary: Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (By similarity). Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (Probable). Through an ubiquitination-dependent mechanism plays also a role in the incorporation of SLC11A2 into extracellular vesicles (By similarity). May play a role in glucose uptake (PubMed:19605364). {ECO:0000250|UniProtKB:A0A0B4J1F4, ECO:0000269|PubMed:19605364, ECO:0000305}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-1.71
RS-1 10μM R08 exp519	-1.7
Atovaquone 15μM R08 exp451	1.81
ABT-702 5μM R06 exp261	2.22
iCRT14 30μM R08 exp492	2.86

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Arrestin N
Arrestin C

protein binding, bridging involved in substrate recognition for ubiquitination
extracellular vesicle biogenesis
positive regulation of ubiquitin-protein transferase activity
regulation of ubiquitin-protein transferase activity
extracellular vesicle
positive regulation of protein ubiquitination
positive regulation of protein modification by small protein conjugation or removal
regulation of protein ubiquitination
regulation of protein modification by small protein conjugation or removal
early endosome
endosome
positive regulation of transferase activity
protein ubiquitination
protein modification by small protein conjugation
regulation of transferase activity
protein modification by small protein conjugation or removal
positive regulation of protein modification process
positive regulation of catalytic activity
protein transport
peptide transport
amide transport
positive regulation of cellular protein metabolic process
establishment of protein localization
positive regulation of protein metabolic process
positive regulation of molecular function
nitrogen compound transport
regulation of protein modification process