ASCL2
Gene Information
- Official Symbol: ASCL2
- Official Name: achaete-scute family bHLH transcription factor 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 430
- UniProt: Q99929
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.
Pfam Domains GO Terms
Pfam Domains
| HLH |
GO Terms
| spongiotrophoblast differentiation |
| negative regulation of Schwann cell proliferation |
| regulation of Schwann cell proliferation |
| spongiotrophoblast layer development |
| negative regulation of glial cell proliferation |
| cell differentiation involved in embryonic placenta development |
| regulation of glial cell proliferation |
| negative regulation of gliogenesis |
| E-box binding |
| somatic stem cell population maintenance |
| RNA polymerase II transcription factor complex |
| embryonic placenta development |
| regulation of gliogenesis |
| stem cell population maintenance |
| maintenance of cell number |
| placenta development |
| protein dimerization activity |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| negative regulation of neurogenesis |
| negative regulation of nervous system development |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| transcription factor binding |
| negative regulation of cell development |
| response to hypoxia |
| response to decreased oxygen levels |
| in utero embryonic development |
| response to oxygen levels |
| reproductive structure development |
| reproductive system development |
| embryonic organ development |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| sensory organ development |
| chordate embryonic development |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| embryo development ending in birth or egg hatching |
| RNA biosynthetic process |
| developmental process involved in reproduction |
| DNA-binding transcription factor activity |
| negative regulation of cell population proliferation |
| negative regulation of cell differentiation |
| regulation of neurogenesis |
| negative regulation of transcription by RNA polymerase II |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| embryo development |
| neuron differentiation |
| nucleobase-containing compound biosynthetic process |
| response to abiotic stimulus |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of cell population proliferation |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| tissue development |
| macromolecule biosynthetic process |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Olaparib 4μM R08 exp512 | 1.83 |
| Palbociclib 1μM R07 exp382 | 2 |
| Dinaciclib 0.007μM R07 exp355 | 2.02 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8575
- Expression level (log2 read counts): -7.68
Expression Distribution
ASCL2 Expression in NALM6 Cells: -7.68
