ASF1A

Entrez Summary: N/A
UniProt Summary: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:10759893, ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 6/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
CHIR-124 0.04μM R06 exp272	-1.91
GSK-J4 1μM R07 exp362	-1.71

DNA replication-dependent nucleosome organization
DNA replication-dependent nucleosome assembly
negative regulation of chromatin silencing
negative regulation of gene silencing
regulation of chromatin silencing
DNA replication-independent nucleosome assembly
DNA replication-independent nucleosome organization
negative regulation of chromatin organization
positive regulation of gene expression, epigenetic
nucleosome assembly
osteoblast differentiation
regulation of gene silencing
histone binding
chromatin assembly
negative regulation of chromosome organization
chromatin assembly or disassembly
nucleosome organization
DNA packaging
regulation of chromatin organization
protein-DNA complex assembly
regulation of gene expression, epigenetic
nuclear chromatin
protein-DNA complex subunit organization
muscle cell differentiation
ossification
DNA conformation change
regulation of chromosome organization
negative regulation of organelle organization
chromatin binding
muscle structure development
DNA repair
protein-containing complex
chromatin organization
negative regulation of cellular component organization
DNA metabolic process
cellular response to DNA damage stimulus
cellular protein-containing complex assembly
chromosome organization
regulation of organelle organization
positive regulation of transcription, DNA-templated