ASF1B

Entrez Summary: N/A
UniProt Summary: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for spermatogenesis. {ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 17/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/25
breast	4/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	3/75
lymphocyte	0/14
ovary	0/26
pancreas	2/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	1/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DNA replication-dependent nucleosome assembly
DNA replication-dependent nucleosome organization
organism emergence from protective structure
hatching
blastocyst hatching
DNA replication-independent nucleosome assembly
DNA replication-independent nucleosome organization
blastocyst development
nucleosome assembly
histone binding
chromatin assembly
chromatin assembly or disassembly
nucleosome organization
DNA packaging
protein-DNA complex assembly
nuclear chromatin
protein-DNA complex subunit organization
DNA conformation change
in utero embryonic development
spermatogenesis
male gamete generation
protein-containing complex
chordate embryonic development
embryo development ending in birth or egg hatching
gamete generation
chromatin organization
multicellular organismal reproductive process
sexual reproduction
cellular protein-containing complex assembly
multicellular organism reproduction
embryo development
multi-organism reproductive process
chromosome organization
reproductive process
reproduction
protein-containing complex assembly
protein-containing complex subunit organization