ASH2L

Entrez Summary: N/A
UniProt Summary: Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis. {ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:19556245}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

euchromatin binding
Set1C/COMPASS complex
MLL3/4 complex
histone methyltransferase activity (H3-K4 specific)
beta-catenin-TCF complex assembly
MLL1 complex
nuclear euchromatin
histone H3-K4 methylation
histone methyltransferase complex
regulation of megakaryocyte differentiation
histone lysine methylation
response to estrogen
beta-catenin binding
peptidyl-lysine methylation
histone methylation
protein methylation
protein alkylation
transcription regulatory region DNA binding
regulation of myeloid cell differentiation
macromolecule methylation
methylation
peptidyl-lysine modification
histone modification
covalent chromatin modification
regulation of hemopoiesis
hemopoiesis
hematopoietic or lymphoid organ development
transcription, DNA-templated
nucleic acid-templated transcription
immune system development
RNA biosynthetic process
chromatin organization
cellular response to DNA damage stimulus
peptidyl-amino acid modification
positive regulation of cell population proliferation
chromosome organization
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
positive regulation of transcription by RNA polymerase II