ASTL

Entrez Summary: N/A
UniProt Summary: Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Rapamycin 2μM plus FK-506 5μM R07 exp308	1.7
LB-100 4.1μM R02 exp72	1.7

glutamic-type peptidase activity
cortical granule
prevention of polyspermy
aspartic-type peptidase activity
negative regulation of binding of sperm to zona pellucida
regulation of binding of sperm to zona pellucida
egg activation
negative regulation of fertilization
positive regulation of protein processing
positive regulation of protein maturation
regulation of fertilization
negative regulation of reproductive process
regulation of protein processing
regulation of protein maturation
transport vesicle
metalloendopeptidase activity
single fertilization
regulation of reproductive process
fertilization
negative regulation of multi-organism process
positive regulation of proteolysis
regulation of proteolysis
regulation of multi-organism process
sexual reproduction
zinc ion binding
cell adhesion
biological adhesion
multi-organism reproductive process
cell activation
proteolysis
reproductive process
reproduction
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
positive regulation of gene expression