ATF2

Gene Information

Official Symbol: ATF2
Official Name: activating transcription factor 2
Aliases and Previous Symbols: N/A
Entrez ID: 1386
UniProt: P15336
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18414
Expression level (log2 read counts): 5.64

Expression Distribution

Screen	Score
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-1.73
39°C R06 exp303	1.73
TGF-beta1 44ng/ml R08 exp528	1.79
INK128 0.2μM R02 exp70	1.86

bZIP 2
bZIP 1

positive regulation of transforming growth factor beta2 production
positive regulation of cardiac muscle myoblast proliferation
regulation of cardiac muscle myoblast proliferation
regulation of transforming growth factor beta2 production
positive regulation of myoblast proliferation
cAMP response element binding protein binding
response to water deprivation
regulation of myoblast proliferation
cAMP response element binding
intra-S DNA damage checkpoint
response to water
positive regulation of mitochondrial membrane permeability involved in apoptotic process
mitochondrial outer membrane permeabilization involved in programmed cell death
positive regulation of transforming growth factor beta production
positive regulation of mitochondrial membrane permeability
amelogenesis
regulation of mitochondrial membrane permeability involved in apoptotic process
positive regulation of membrane permeability
enhancer sequence-specific DNA binding
regulation of transforming growth factor beta production
adipose tissue development
histone acetyltransferase activity
RNA polymerase II activating transcription factor binding
positive regulation of neuron apoptotic process
site of double-strand break
apoptotic mitochondrial changes
regulation of mitochondrial membrane permeability
outflow tract morphogenesis
response to osmotic stress
regulation of membrane permeability
odontogenesis of dentin-containing tooth
positive regulation of neuron death
mitotic DNA damage checkpoint
RNA polymerase II distal enhancer sequence-specific DNA binding
negative regulation of angiogenesis
mitotic DNA integrity checkpoint
negative regulation of blood vessel morphogenesis
fat cell differentiation
histone acetylation
negative regulation of vasculature development