ATF3

Gene Information

Official Symbol: ATF3
Official Name: activating transcription factor 3
Aliases and Previous Symbols: N/A
Entrez ID: 467
UniProt: P18847
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011].
UniProt Summary: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18462
Expression level (log2 read counts): 2.42

Expression Distribution

bZIP 1
bZIP 2

CHOP-ATF3 complex
regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance
positive regulation of TRAIL-activated apoptotic signaling pathway
regulation of TRAIL-activated apoptotic signaling pathway
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
PERK-mediated unfolded protein response
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
cellular response to arsenic-containing substance
positive regulation of transcription from RNA polymerase II promoter in response to stress
response to arsenic-containing substance
ER-nucleus signaling pathway
cellular response to amino acid starvation
gluconeogenesis
response to amino acid starvation
hexose biosynthetic process
positive regulation of extrinsic apoptotic signaling pathway
skeletal muscle cell differentiation
monosaccharide biosynthetic process
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of ERK1 and ERK2 cascade
transcription regulatory region sequence-specific DNA binding
endoplasmic reticulum unfolded protein response
glucose metabolic process
regulation of transcription from RNA polymerase II promoter in response to stress
skeletal muscle tissue development
regulation of DNA-templated transcription in response to stress
cellular response to unfolded protein
carbohydrate biosynthetic process
skeletal muscle organ development
cellular response to topologically incorrect protein
cellular response to starvation
regulation of extrinsic apoptotic signaling pathway
hexose metabolic process
response to unfolded protein
negative regulation of MAPK cascade
positive regulation of apoptotic signaling pathway
response to topologically incorrect protein
response to starvation
monosaccharide metabolic process
transcription regulatory region DNA binding