ATP2C2

Entrez Summary: N/A
UniProt Summary: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

manganese transmembrane transporter activity, phosphorylative mechanism
manganese ion transmembrane transport
calcium transmembrane transporter activity, phosphorylative mechanism
manganese ion transport
proton-exporting ATPase activity, phosphorylative mechanism
positive regulation of calcium ion import
regulation of calcium ion import
cytoplasmic side of plasma membrane
mammary gland epithelium development
transition metal ion transport
positive regulation of calcium ion transport
mammary gland development
proton transmembrane transport
protein localization to plasma membrane
calcium ion transmembrane transport
protein localization to cell periphery
regulation of calcium ion transport
calcium ion transport
cytoplasmic vesicle
positive regulation of ion transport
divalent metal ion transport
divalent inorganic cation transport
regulation of metal ion transport
monovalent inorganic cation transport
gland development
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
protein localization to membrane
divalent inorganic cation homeostasis
cellular metal ion homeostasis
inorganic cation transmembrane transport
cation transmembrane transport
Golgi membrane
metal ion homeostasis
cellular cation homeostasis
metal ion transport
cellular ion homeostasis
inorganic ion transmembrane transport
perinuclear region of cytoplasm