ATP7A

Entrez Summary: This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked distal spinal muscular atrophy, and occipital horn syndrome. Alternatively-spliced transcript variants have been observed. [provided by RefSeq, Aug 2013].
UniProt Summary: May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
PF-06409577 20μM R07 exp389	-1.92
UM0130462 0.025 to 0.035μM day4 R05 exp247	-1.75
Campthothecin 0.001μM R06 exp270	1.94
Trientine 500μM R08 exp534	4.91
Ammonium tetrathiomolybdate 10μM R08 exp448	8.49

Global Fraction of Cell Lines Where Essential: 1/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	1/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

elastin biosynthetic process
copper ion export
copper transmembrane transporter activity, phosphorylative mechanism
copper-dependent protein binding
negative regulation of iron ion transmembrane transport
epinephrine metabolic process
superoxide dismutase copper chaperone activity
negative regulation of iron ion transport
cellular response to cobalt ion
regulation of iron ion transmembrane transport
copper ion transmembrane transporter activity
regulation of cytochrome-c oxidase activity
elastin metabolic process
cellular response to lead ion
response to iron(III) ion
cuprous ion binding
copper ion transmembrane transport
regulation of electron transfer activity
copper ion import
regulation of iron ion transport
pyramidal neuron development
pyramidal neuron differentiation
elastic fiber assembly
cerebellar Purkinje cell differentiation
response to cobalt ion
serotonin metabolic process
cerebellar Purkinje cell layer formation
cellular response to iron ion
positive regulation of cell size
tryptophan metabolic process
removal of superoxide radicals
norepinephrine metabolic process
primary amino compound metabolic process
cerebellar Purkinje cell layer morphogenesis
cellular copper ion homeostasis
cellular response to superoxide
cellular response to oxygen radical
detoxification of copper ion
trans-Golgi network transport vesicle
stress response to copper ion