AVIL

Gene Information

Official Symbol: AVIL
Official Name: advillin
Aliases and Previous Symbols: N/A
Entrez ID: 10677
UniProt: O75366
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. {ECO:0000269|PubMed:20393563}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dihydrosphingosine 8μM R08 exp476	-2.08
Caffeine 2600μM R08 exp463	-1.73
UM0131023 0.05μM R05 exp248	-1.72
Oligomycin-A 20μM R00 exp26	-1.7
Hypoxia 5%O2 R04 exp191	1.86
AICAR 240μM R03 exp116	2.05

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7782
Expression level (log2 read counts): 3.36

Expression Distribution

VHP
Gelsolin

actin filament capping
negative regulation of actin filament depolymerization
regulation of actin filament depolymerization
negative regulation of actin filament polymerization
negative regulation of protein depolymerization
negative regulation of protein polymerization
negative regulation of protein complex disassembly
regulation of protein depolymerization
cell projection
regulation of protein complex disassembly
negative regulation of protein complex assembly
negative regulation of supramolecular fiber organization
negative regulation of cytoskeleton organization
regulation of actin filament polymerization
regulation of actin polymerization or depolymerization
regulation of actin filament length
actin filament binding
actin cytoskeleton
regulation of protein polymerization
regulation of actin filament organization
actin binding
positive regulation of neuron projection development
axon
neuron projection
regulation of actin cytoskeleton organization
cilium assembly
regulation of supramolecular fiber organization
cilium organization
positive regulation of neuron differentiation
negative regulation of organelle organization
regulation of cellular component size
positive regulation of cell projection organization
regulation of actin filament-based process
plasma membrane bounded cell projection assembly
regulation of protein complex assembly
cell projection assembly
positive regulation of neurogenesis
regulation of neuron projection development
regulation of anatomical structure size
positive regulation of nervous system development