B3GNT3

Official Symbol: B3GNT3
Official Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Aliases and Previous Symbols: N/A
Entrez ID: 10331
UniProt: Q9Y2A9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein and contains a signal anchor that is not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains and the biosynthesis of the backbone structure of dimeric sialyl Lewis a. It plays dominant roles in L-selectin ligand biosynthesis, lymphocyte homing and lymphocyte trafficking. [provided by RefSeq, Jul 2008].
UniProt Summary: Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides (PubMed:11042166). Also acts as a core1-1,3-N- acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the 6- sulfo sialyl Lewis x on extended core1 O-glycans (PubMed:11439191). {ECO:0000269|PubMed:11042166, ECO:0000269|PubMed:11439191}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
proTAME 5μM R04 exp187	1.72
Chloramphenicol 2μM R00 exp12	2.04

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity
poly-N-acetyllactosamine biosynthetic process
poly-N-acetyllactosamine metabolic process
galactosyltransferase activity
acetylgalactosaminyltransferase activity
keratan sulfate biosynthetic process
keratan sulfate metabolic process
cellular polysaccharide biosynthetic process
polysaccharide biosynthetic process
cellular carbohydrate biosynthetic process
O-glycan processing
cellular polysaccharide metabolic process
polysaccharide metabolic process
glycosaminoglycan biosynthetic process
mucopolysaccharide metabolic process
aminoglycan biosynthetic process
protein O-linked glycosylation
carbohydrate biosynthetic process
glycosaminoglycan metabolic process
aminoglycan metabolic process
cellular carbohydrate metabolic process
sulfur compound biosynthetic process
protein glycosylation
macromolecule glycosylation
glycosylation
glycoprotein biosynthetic process
sulfur compound metabolic process
glycoprotein metabolic process
carbohydrate metabolic process
Golgi membrane
carbohydrate derivative biosynthetic process
Golgi apparatus
oxoacid metabolic process
endoplasmic reticulum
organic acid metabolic process
carbohydrate derivative metabolic process
integral component of plasma membrane
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process