BCAP31

Gene Information

Official Symbol: BCAP31
Official Name: B cell receptor associated protein 31
Aliases and Previous Symbols: N/A
Entrez ID: 10134
UniProt: P51572
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the B-cell receptor associated protein 31 superfamily. The encoded protein is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in caspase 8-mediated apoptosis. Microdeletions in this gene are associated with contiguous ABCD1/DXS1375E deletion syndrome (CADDS), a neonatal disorder. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 16. [provided by RefSeq, Jan 2012].
UniProt Summary: Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD). Also serves as a cargo receptor for the export of transmembrane proteins. May be involved in CASP8- mediated apoptosis. {ECO:0000269|PubMed:10958671, ECO:0000269|PubMed:18287538, ECO:0000269|PubMed:9396746}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Golgicide-A 4μM R03 exp122	-2.22
Dihydrosphingosine 8μM R08 exp476	-1.87
Thimerosal 0.85μM R08 exp529	-1.87
PU-H71 1μM R08 exp515	-1.84
DKK1 89ng/ml R08 exp477	-1.76
Trientine 500μM R08 exp534	1.87

Global Fraction of Cell Lines Where Essential: 3/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	1/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18114
Expression level (log2 read counts): 6.73

Expression Distribution

positive regulation of retrograde protein transport, ER to cytosol
positive regulation of ER-associated ubiquitin-dependent protein catabolic process
protein localization to endoplasmic reticulum exit site
negative regulation of endoplasmic reticulum calcium ion concentration
regulation of ER-associated ubiquitin-dependent protein catabolic process
positive regulation of mitochondrial calcium ion concentration
regulation of retrograde protein transport, ER to cytosol
positive regulation of protein exit from endoplasmic reticulum
positive regulation of ERAD pathway
perinuclear endoplasmic reticulum
MHC class I protein binding
endoplasmic reticulum calcium ion homeostasis
calcium-mediated signaling using intracellular calcium source
mitochondrial calcium ion homeostasis
regulation of protein exit from endoplasmic reticulum
regulation of ERAD pathway
integral component of lumenal side of endoplasmic reticulum membrane
positive regulation of response to endoplasmic reticulum stress
clathrin-coated vesicle
positive regulation of intrinsic apoptotic signaling pathway
endoplasmic reticulum-Golgi intermediate compartment membrane
lipid droplet
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of response to endoplasmic reticulum stress
Golgi cisterna membrane
antigen processing and presentation of peptide antigen via MHC class I
positive regulation of ubiquitin-dependent protein catabolic process
positive regulation of proteasomal protein catabolic process
positive regulation of proteolysis involved in cellular protein catabolic process
regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein localization to endoplasmic reticulum
positive regulation of cellular protein catabolic process
calcium-mediated signaling
positive regulation of cysteine-type endopeptidase activity
regulation of ubiquitin-dependent protein catabolic process
positive regulation of intracellular protein transport
regulation of intrinsic apoptotic signaling pathway
positive regulation of endopeptidase activity
positive regulation of apoptotic signaling pathway