BCAR3

Entrez Summary: N/A
UniProt Summary: May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins. {ECO:0000269|PubMed:9582273}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

SH2
RasGEF

lens morphogenesis in camera-type eye
lens development in camera-type eye
guanyl-nucleotide exchange factor activity
positive regulation of peptidyl-serine phosphorylation
camera-type eye morphogenesis
regulation of peptidyl-serine phosphorylation
eye morphogenesis
sensory organ morphogenesis
camera-type eye development
small GTPase mediated signal transduction
eye development
visual system development
sensory system development
sensory organ development
animal organ morphogenesis
positive regulation of protein phosphorylation
response to drug
positive regulation of phosphorylation
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
positive regulation of protein modification process
regulation of protein phosphorylation
regulation of phosphorylation
positive regulation of cellular protein metabolic process
intracellular signal transduction
positive regulation of protein metabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process