BCAS2

Entrez Summary: N/A
UniProt Summary: Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). {ECO:0000269|PubMed:24332808}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 35/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	1/26
breast	2/33
central nervous system	0/56
cervix	0/4
colorectal	2/17
esophagus	1/13
fibroblast	0/1
gastric	2/16
kidney	0/21
liver	0/20
lung	3/75
lymphocyte	1/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	4/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	0/29
uterus	1/5

Expression Distribution

Prp19 complex
DNA replication factor A complex
U2-type catalytic step 2 spliceosome
spliceosomal complex
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
RNA splicing
nuclear speck
mRNA processing
centrosome
mRNA metabolic process
nucleolus
RNA processing
RNA metabolic process
gene expression