BEND3

Entrez Summary: N/A
UniProt Summary: Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). {ECO:0000250|UniProtKB:Q6PAL0, ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:28977671}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tanespimycin 14μM R08 exp527	1.77
Dinaciclib 0.007μM R07 exp355	1.78
UM131593 0.2μM R03 exp106	1.86
TNF-alpha 44ng/ml R08 exp533	2.02
Trientine 500μM R08 exp534	2.21
I-BRD9 4μM R07 exp365	2.23
TRAIL 50ng/ml R00 exp36	2.34
Fluvastatin 2.2μM R06 exp282	2.36
Pimelic-diphenylamide-106 5μM R00 exp28	2.64
TRAIL 5ng/ml R00 exp35	2.76
Amiloride 100μM R08 exp447	3
THZ531 0.11μM R07 exp409	3.47
THZ531 0.11 to 0.125μM on day4 R07 exp410	4.14
Nifuroxazide 5μM R03 exp102	4.31
THZ531 0.11 to 0.175μM on day4 R07 exp413	6.37
ML-792 0.2μM R08 exp505	6.42
THZ1 0.06μM R08 exp531	7.22
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	7.43
THZ531 0.225μM R08 exp444	8.1
MLN-4924 0.2μM R00 exp21	8.48

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

histone H3-K9 trimethylation
rDNA binding
histone H4-K20 trimethylation
histone H3-K27 trimethylation
histone H4-K20 methylation
histone H3-K27 methylation
chromatin silencing at rDNA
histone H3-K9 methylation
histone H3-K4 trimethylation
histone H3-K9 modification
nuclear heterochromatin
peptidyl-lysine trimethylation
histone H3-K4 methylation
positive regulation of ATP metabolic process
DNA alkylation
DNA methylation
histone H4 acetylation
chromatin organization involved in negative regulation of transcription
chromatin silencing
DNA methylation or demethylation
chromatin organization involved in regulation of transcription
histone lysine methylation
negative regulation of gene expression, epigenetic
peptidyl-lysine methylation
DNA modification
histone methylation
histone acetylation
internal peptidyl-lysine acetylation
regulation of ATP metabolic process
peptidyl-lysine acetylation
internal protein amino acid acetylation
protein alkylation
protein methylation
protein acetylation
gene silencing
protein acylation
regulation of gene expression, epigenetic
macromolecule methylation
methylation
peptidyl-lysine modification