BGN

Entrez Summary: This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication. [provided by RefSeq, Nov 2015].
UniProt Summary: May be involved in collagen fiber assembly. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
dermatan sulfate biosynthetic process
dermatan sulfate metabolic process
chondroitin sulfate catabolic process
dermatan sulfate proteoglycan biosynthetic process
extracellular matrix structural constituent conferring compression resistance
dermatan sulfate proteoglycan metabolic process
glycosaminoglycan binding
chondroitin sulfate biosynthetic process
extracellular matrix binding
chondroitin sulfate proteoglycan biosynthetic process
blood vessel remodeling
chondroitin sulfate metabolic process
chondroitin sulfate proteoglycan metabolic process
sulfur compound catabolic process
peptide cross-linking
glycosaminoglycan catabolic process
aminoglycan catabolic process
proteoglycan biosynthetic process
transport vesicle
proteoglycan metabolic process
lysosomal lumen
sarcolemma
tissue remodeling
Golgi lumen
glycosaminoglycan biosynthetic process
mucopolysaccharide metabolic process
aminoglycan biosynthetic process
extracellular matrix structural constituent
glycosaminoglycan metabolic process
aminoglycan metabolic process
sulfur compound biosynthetic process
monocarboxylic acid biosynthetic process
carbohydrate derivative catabolic process
peptidyl-serine modification
extracellular matrix
carboxylic acid biosynthetic process
organic acid biosynthetic process
glycoprotein biosynthetic process
extracellular matrix organization