BHMT

Entrez Summary: This gene encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in this gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed. [provided by RefSeq, Jul 2008].
UniProt Summary: Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of homocysteine metabolic process
betaine-homocysteine S-methyltransferase activity
regulation of sulfur amino acid metabolic process
amino-acid betaine catabolic process
choline catabolic process
L-methionine biosynthetic process
L-methionine salvage
amino acid salvage
choline metabolic process
methionine biosynthetic process
regulation of sulfur metabolic process
methionine metabolic process
amino-acid betaine metabolic process
S-adenosylmethionine metabolic process
sulfur amino acid biosynthetic process
cellular biogenic amine catabolic process
amine catabolic process
neurotransmitter catabolic process
aspartate family amino acid biosynthetic process
cellular modified amino acid catabolic process
cellular metabolic compound salvage
sulfur amino acid metabolic process
aspartate family amino acid metabolic process
cellular biogenic amine metabolic process
cellular amine metabolic process
regulation of cellular amino acid metabolic process
alpha-amino acid biosynthetic process
amine metabolic process
regulation of cellular amine metabolic process
cellular amino acid biosynthetic process
neurotransmitter metabolic process
protein alkylation
protein methylation
regulation of cellular ketone metabolic process
sulfur compound biosynthetic process
ammonium ion metabolic process
cellular modified amino acid metabolic process
alpha-amino acid metabolic process
coenzyme metabolic process
macromolecule methylation