BLMH

Entrez Summary: Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. [provided by RefSeq, Jul 2008].
UniProt Summary: The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Trimetrexate 0.03μM R08 exp535	-2.12
5-Fluorouracil 20μM R00 exp2	-1.94
RK-33 8μM R08 exp518	-1.85
LY2090314 0.003μM R08 exp499	-1.8
ABT-702 5μM R06 exp261	-1.72
Dimethyloxaloylglycine 100μM R05 exp229	1.77
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	2.02
A-366 10μM R03 exp115	2.07

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

homocysteine catabolic process
homocysteine metabolic process
sulfur amino acid catabolic process
carboxypeptidase activity
aminopeptidase activity
cysteine-type peptidase activity
sulfur amino acid metabolic process
sulfur compound catabolic process
cysteine-type endopeptidase activity
alpha-amino acid catabolic process
cellular amino acid catabolic process
alpha-amino acid metabolic process
carboxylic acid catabolic process
organic acid catabolic process
protein polyubiquitination
cellular amino acid metabolic process
sulfur compound metabolic process
small molecule catabolic process
response to toxic substance
protein ubiquitination
protein modification by small protein conjugation
carboxylic acid metabolic process
protein modification by small protein conjugation or removal
oxoacid metabolic process
response to drug
organic acid metabolic process
organonitrogen compound catabolic process
identical protein binding
proteolysis
small molecule metabolic process
organic substance catabolic process
cellular catabolic process