BLVRA

Entrez Summary: The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH. Mutations in this gene are associated with hyperbiliverdinemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011].
UniProt Summary: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Biliv-reduc cat
GFO IDH MocA

biliverdin reductase activity
tetrapyrrole catabolic process
heme catabolic process
pigment catabolic process
porphyrin-containing compound catabolic process
heme metabolic process
porphyrin-containing compound metabolic process
tetrapyrrole metabolic process
cofactor catabolic process
pigment metabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
cofactor metabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
zinc ion binding
oxidation-reduction process
organonitrogen compound catabolic process
organic substance catabolic process
cellular catabolic process