BNC2

Entrez Summary: This gene encodes a conserved zinc finger protein. The encoded protein functions in skin color saturation. Mutations in this gene are associated with facial pigmented spots. This gene is also associated with susceptibility to adolescent idiopathic scoliosis. [provided by RefSeq, Jul 2016].
UniProt Summary: Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Trichostatin-A 0.06μM R07 exp415	1.86
Bafilomycin-A1 0.009μM R08 exp454	2.06

tongue development
endochondral bone growth
bone growth
roof of mouth development
organ growth
mesenchyme development
developmental growth
growth
sensory organ development
DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
tissue development