BPI

Gene Information

Official Symbol: BPI
Official Name: bactericidal permeability increasing protein
Aliases and Previous Symbols: N/A
Entrez ID: 671
UniProt: P17213
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7891
Expression level (log2 read counts): -0.46

Expression Distribution

Screen	Score
CCT251545 20μM R07 exp326	-1.96
CFI-400945 25μM R08 exp469	-1.71
IU1-47 25μM R04 exp182	1.88

LBP BPI CETP C
LBP BPI CETP

negative regulation of macrophage activation
negative regulation of interleukin-8 production
lipopolysaccharide-mediated signaling pathway
lipopolysaccharide binding
negative regulation of interleukin-6 production
regulation of macrophage activation
negative regulation of tumor necrosis factor production
negative regulation of tumor necrosis factor superfamily cytokine production
specific granule lumen
regulation of interleukin-8 production
defense response to Gram-negative bacterium
azurophil granule lumen
antimicrobial humoral response
regulation of interleukin-6 production
regulation of tumor necrosis factor production
regulation of tumor necrosis factor superfamily cytokine production
negative regulation of leukocyte activation
cellular response to lipopolysaccharide
cellular response to molecule of bacterial origin
negative regulation of cell activation
cellular response to biotic stimulus
negative regulation of cytokine production
response to lipopolysaccharide
response to molecule of bacterial origin
defense response to bacterium
humoral immune response
negative regulation of immune system process
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
cellular response to lipid
myeloid cell activation involved in immune response
myeloid leukocyte activation
regulation of leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response