BRF2

Official Symbol: BRF2
Official Name: BRF2 RNA polymerase III transcription initiation factor subunit
Aliases and Previous Symbols: N/A
Entrez ID: 55290
UniProt: Q9HAW0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein. [provided by RefSeq, Jul 2008].
UniProt Summary: General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (PubMed:11040218, PubMed:11121026, PubMed:11564744, PubMed:26638071). Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress (PubMed:26638071). Down-regulates expression of target genes in response to oxidative stress (PubMed:26638071). Overexpression protects cells against apoptosis in response to oxidative stress (PubMed:26638071). {ECO:0000269|PubMed:11040218, ECO:0000269|PubMed:11121026, ECO:0000269|PubMed:11564744, ECO:0000269|PubMed:26638071}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
AICAR 240μM R05 exp211	-1.94
ML-792 0.2μM R08 exp505	-1.78
GSK-J4 1.5μM R08 exp441	-1.73
NN-Diethyl-meta-toluamide 100μM R05 exp237	1.71
Apcin 50 to 100μM on day4 R04 exp176	1.72
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	1.74
Golgicide-A 4μM R03 exp122	1.88

Global Fraction of Cell Lines Where Essential: 735/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	27/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	74/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

RNA polymerase III type 3 promoter sequence-specific DNA binding
RNA polymerase III type 3 promoter DNA binding
transcription factor TFIIIB complex
RNA polymerase III preinitiation complex assembly
transcription initiation from RNA polymerase III promoter
regulation of transcription by RNA polymerase III
transcription preinitiation complex assembly
transcription by RNA polymerase III
protein-DNA complex assembly
DNA-templated transcription, initiation
cellular response to oxidative stress
protein-DNA complex subunit organization
transcription factor binding
response to oxidative stress
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
cellular protein-containing complex assembly
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
protein-containing complex assembly
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular response to stress
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
gene expression