BTN2A2
Gene Information
- Official Symbol: BTN2A2
- Official Name: butyrophilin subfamily 2 member A2
- Aliases and Previous Symbols: N/A
- Entrez ID: 10385
- UniProt: Q8WVV5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| SPRY |
| V-set |
GO Terms
| negative regulation of activated T cell proliferation |
| negative regulation of phosphatidylinositol 3-kinase signaling |
| positive regulation of regulatory T cell differentiation |
| negative regulation of T cell receptor signaling pathway |
| negative regulation of antigen receptor-mediated signaling pathway |
| regulation of regulatory T cell differentiation |
| regulation of activated T cell proliferation |
| regulation of T cell receptor signaling pathway |
| negative regulation of protein kinase B signaling |
| negative regulation of T cell proliferation |
| regulation of antigen receptor-mediated signaling pathway |
| negative regulation of ERK1 and ERK2 cascade |
| negative regulation of cytokine secretion |
| negative regulation of lymphocyte proliferation |
| negative regulation of mononuclear cell proliferation |
| negative regulation of leukocyte proliferation |
| positive regulation of T cell differentiation |
| positive regulation of lymphocyte differentiation |
| negative regulation of G1/S transition of mitotic cell cycle |
| negative regulation of cell cycle G1/S phase transition |
| negative regulation of T cell activation |
| regulation of phosphatidylinositol 3-kinase signaling |
| negative regulation of leukocyte cell-cell adhesion |
| negative regulation of protein secretion |
| regulation of T cell differentiation |
| negative regulation of peptide secretion |
| negative regulation of lymphocyte activation |
| positive regulation of leukocyte differentiation |
| regulation of G1/S transition of mitotic cell cycle |
| regulation of T cell proliferation |
| regulation of cell cycle G1/S phase transition |
| negative regulation of MAPK cascade |
| regulation of lymphocyte differentiation |
| negative regulation of leukocyte activation |
| negative regulation of cell-cell adhesion |
| T cell receptor signaling pathway |
| negative regulation of protein transport |
| negative regulation of establishment of protein localization |
| positive regulation of hemopoiesis |
| negative regulation of cell activation |
| positive regulation of T cell activation |
| negative regulation of secretion by cell |
| regulation of cytokine secretion |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| negative regulation of mitotic cell cycle phase transition |
| positive regulation of leukocyte cell-cell adhesion |
| regulation of protein kinase B signaling |
| regulation of leukocyte proliferation |
| negative regulation of cell cycle phase transition |
| negative regulation of secretion |
| positive regulation of cell-cell adhesion |
| negative regulation of cell adhesion |
| regulation of leukocyte differentiation |
| negative regulation of cytokine production |
| regulation of ERK1 and ERK2 cascade |
| antigen receptor-mediated signaling pathway |
| regulation of leukocyte cell-cell adhesion |
| negative regulation of mitotic cell cycle |
| regulation of T cell activation |
| negative regulation of cell cycle process |
| signaling receptor binding |
| positive regulation of lymphocyte activation |
| external side of plasma membrane |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| negative regulation of protein phosphorylation |
| regulation of mitotic cell cycle phase transition |
| positive regulation of cell activation |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| regulation of cell cycle phase transition |
| immune response-activating cell surface receptor signaling pathway |
| regulation of hemopoiesis |
| regulation of protein secretion |
| immune response-regulating cell surface receptor signaling pathway |
| negative regulation of transport |
| regulation of peptide secretion |
| negative regulation of intracellular signal transduction |
| regulation of lymphocyte activation |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| immune response-activating signal transduction |
| negative regulation of cell cycle |
| negative regulation of protein modification process |
| immune response-regulating signaling pathway |
| regulation of leukocyte activation |
| regulation of mitotic cell cycle |
| activation of immune response |
| regulation of cell activation |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| regulation of cytokine production |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of cell cycle process |
| regulation of MAPK cascade |
| regulation of secretion |
| positive regulation of immune response |
| positive regulation of cell differentiation |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| regulation of cell cycle |
| negative regulation of multicellular organismal process |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| regulation of protein phosphorylation |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| regulation of immune system process |
| positive regulation of multicellular organismal process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17333
- Expression level (log2 read counts): 5.59
Expression Distribution
BTN2A2 Expression in NALM6 Cells: 5.59
