C11orf63

Entrez Summary: N/A
UniProt Summary: Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces. {ECO:0000250|UniProtKB:E9Q793}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Deferoxamine 11μM R07 exp350	-1.8
Monensin 0.3μM R08 exp507	-1.8
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	-1.7
UM0131023 0.05μM R05 exp248	1.85
Dihydrosphingosine 8μM R08 exp476	2.06

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cerebrospinal fluid secretion
ciliary basal body organization
secretion by tissue
axoneme assembly
body fluid secretion
microtubule bundle formation
microtubule organizing center organization
cilium assembly
cilium organization
plasma membrane bounded cell projection assembly
cell projection assembly
microtubule cytoskeleton organization
regulation of body fluid levels
microtubule-based process
brain development
organelle assembly
head development
central nervous system development
cytoskeleton organization
plasma membrane bounded cell projection organization
secretion
cell projection organization