C11orf83

Gene Information

Official Symbol: UQCC3
Official Name: ubiquinol-cytochrome c reductase complex assembly factor 3
Aliases and Previous Symbols: N/A
Entrez ID: 790955
UniProt: Q6UW78
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Complex III is a mitochondrial inner membrane protein complex that transfers electrons from ubiquinol to cytochrome c. This gene encodes a protein that functions in complex III assembly. Mutations in this gene result in Mitochondrial complex III deficiency, nuclear type 9. [provided by RefSeq, Dec 2014].
UniProt Summary: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin- binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology. {ECO:0000269|PubMed:25008109, ECO:0000269|PubMed:25605331}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2368
Expression level (log2 read counts): 4.2

Expression Distribution

Screen	Score
Bisphenol S 100μM R08 exp458	1.75
I-BRD9 4μM R07 exp365	1.77

mitochondrial respiratory chain complex III assembly
respiratory chain complex III assembly
cardiolipin binding
mitochondrial respiratory chain complex III
mitochondrial electron transport, ubiquinol to cytochrome c
phosphatidic acid binding
cristae formation
cytochrome complex assembly
ATP biosynthetic process
integral component of mitochondrial inner membrane
inner mitochondrial membrane organization
purine ribonucleoside triphosphate biosynthetic process
purine nucleoside triphosphate biosynthetic process
ribonucleoside triphosphate biosynthetic process
purine ribonucleoside triphosphate metabolic process
nucleoside triphosphate biosynthetic process
ribonucleoside triphosphate metabolic process
purine nucleoside triphosphate metabolic process
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
nucleoside triphosphate metabolic process
mitochondrial respiratory chain complex assembly
respiratory electron transport chain
oxidative phosphorylation
mitochondrial membrane organization
purine ribonucleotide biosynthetic process
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
cellular respiration
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
electron transport chain
ATP metabolic process
energy derivation by oxidation of organic compounds
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process