C19orf10

Entrez Summary: N/A
UniProt Summary: Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518). {ECO:0000250|UniProtKB:Q9CPT4, ECO:0000269|PubMed:25581518}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

IRE1-mediated unfolded protein response
endoplasmic reticulum-Golgi intermediate compartment
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of endothelial cell proliferation
endoplasmic reticulum unfolded protein response
regulation of phosphatidylinositol 3-kinase signaling
cellular response to unfolded protein
regulation of endothelial cell proliferation
cellular response to topologically incorrect protein
response to unfolded protein
positive regulation of angiogenesis
positive regulation of protein kinase B signaling
positive regulation of vasculature development
response to topologically incorrect protein
positive regulation of epithelial cell proliferation
regulation of protein kinase B signaling
response to endoplasmic reticulum stress
regulation of angiogenesis
endoplasmic reticulum lumen
angiogenesis
regulation of vasculature development
regulation of epithelial cell proliferation
blood vessel morphogenesis
blood vessel development
vasculature development
cardiovascular system development
positive regulation of MAPK cascade
tube morphogenesis
regulation of MAPK cascade
tube development
circulatory system development
negative regulation of apoptotic process
anatomical structure formation involved in morphogenesis
negative regulation of programmed cell death
positive regulation of cell population proliferation
apoptotic process
Golgi apparatus
negative regulation of cell death
endoplasmic reticulum
positive regulation of protein phosphorylation