C19orf66

Gene Information
  • Official Symbol: SHFL
  • Official Name: shiftless antiviral inhibitor of ribosomal frameshifting
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 55337
  • UniProt: Q9NUL5
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: N/A
  • UniProt Summary: Exhibits antiviral activity against dengue virus (DENV) and can inhibit the replication of all DENV serotypes. May block the protein translation of DENV RNA via its association with cellular mRNA-binding proteins and viral RNA. Can also limit the replication of hepatitis C virus (HCV), West Nile virus (WNV), Chikungunya virus (CHIKV), herpes simplex virus type 1 (HHV-1) and human adenovirus (PubMed:26735137). {ECO:0000269|PubMed:26735137}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 4897
  • Expression level (log2 read counts): 4.46

Expression Distribution

  • Last modified: 2026/01/07 22:36
  • by 127.0.0.1