C21orf2

Entrez Summary: N/A
UniProt Summary: Plays a role in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). Involved in DNA damage repair (PubMed:26290490). {ECO:0000250|UniProtKB:Q8C6G1, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:26290490}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
ETC-159 50μM R08 exp480	2.08
Aminopterin 0.005μM R07 exp335	2.72

DNA damage response, detection of DNA damage
photoreceptor connecting cilium
photoreceptor outer segment
ciliary basal body
regulation of cell shape
cilium assembly
cilium organization
plasma membrane bounded cell projection assembly
cell projection assembly
regulation of cell morphogenesis
detection of stimulus
organelle assembly
molecular function
cellular response to DNA damage stimulus
regulation of anatomical structure morphogenesis
cytoskeleton organization
plasma membrane bounded cell projection organization
cell projection organization
mitochondrion
cellular response to stress