C4orf26

Entrez Summary: Dental enamel forms the outer cap of teeth and is the hardest substance found in vertebrates. This gene is thought to encode an extracellular matrix acidic phosphoprotein that has a function in enamel mineralization during amelogenesis. Mutations in this gene are associated with recessive hypomineralized amelogenesis imperfecta. [provided by RefSeq, Oct 2012].
UniProt Summary: May promote nucleation of hydroxyapatite. {ECO:0000269|PubMed:22901946}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of enamel mineralization
positive regulation of odontogenesis of dentin-containing tooth
regulation of enamel mineralization
positive regulation of tooth mineralization
regulation of tooth mineralization
positive regulation of odontogenesis
regulation of odontogenesis of dentin-containing tooth
regulation of odontogenesis
positive regulation of biomineral tissue development
positive regulation of biomineralization
positive regulation of animal organ morphogenesis
regulation of biomineralization
regulation of biomineral tissue development
regulation of animal organ morphogenesis
regulation of anatomical structure morphogenesis
positive regulation of developmental process
positive regulation of multicellular organismal process
extracellular region