C5orf45

Gene Information

Official Symbol: MRNIP
Official Name: MRN complex interacting protein
Aliases and Previous Symbols: N/A
Entrez ID: 51149
UniProt: Q6NTE8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex (PubMed:27568553). Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair (PubMed:27568553).

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17781
Expression level (log2 read counts): 5.95

Expression Distribution

Mre11 complex
positive regulation of double-strand break repair via homologous recombination
mitotic G2 DNA damage checkpoint
protein localization to chromatin
regulation of double-strand break repair via nonhomologous end joining
mitotic G2/M transition checkpoint
G2 DNA damage checkpoint
positive regulation of double-strand break repair
positive regulation of DNA recombination
regulation of double-strand break repair via homologous recombination
protein localization to chromosome
positive regulation of DNA repair
regulation of double-strand break repair
negative regulation of G2/M transition of mitotic cell cycle
mitotic DNA damage checkpoint
positive regulation of response to DNA damage stimulus
negative regulation of cell cycle G2/M phase transition
regulation of DNA recombination
mitotic DNA integrity checkpoint
regulation of DNA repair
DNA damage checkpoint
DNA integrity checkpoint
response to ionizing radiation
mitotic cell cycle checkpoint
positive regulation of DNA metabolic process
cell cycle checkpoint
regulation of G2/M transition of mitotic cell cycle
regulation of cell cycle G2/M phase transition
negative regulation of mitotic cell cycle phase transition
regulation of response to DNA damage stimulus
negative regulation of cell cycle phase transition
negative regulation of mitotic cell cycle
negative regulation of cell cycle process
regulation of DNA metabolic process
chromatin binding
regulation of mitotic cell cycle phase transition
response to radiation
regulation of cell cycle phase transition
DNA repair
positive regulation of protein kinase activity