CALCOCO1

Gene Information

Official Symbol: CALCOCO1
Official Name: calcium binding and coiled-coil domain 1
Aliases and Previous Symbols: N/A
Entrez ID: 57658
UniProt: Q9P1Z2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: N/A
UniProt Summary: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1- mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000250|UniProtKB:Q8CGU1, ECO:0000269|PubMed:24245781}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7834
Expression level (log2 read counts): 4.31

Expression Distribution

Screen	Score
UNC1999 2μM R03 exp155	1.86
Cycloheximide 0.02μM R00 exp14	1.98
Vinblastine 0.002μM R01 exp60	2.13

armadillo repeat domain binding
nuclear receptor transcription coactivator activity
intracellular steroid hormone receptor signaling pathway
transcription coregulator activity
beta-catenin binding
RNA polymerase II distal enhancer sequence-specific DNA binding
steroid hormone mediated signaling pathway
intracellular receptor signaling pathway
hormone-mediated signaling pathway
cellular response to steroid hormone stimulus
protein C-terminus binding
transcription regulatory region DNA binding
nuclear chromatin
transcription coactivator activity
response to steroid hormone
Wnt signaling pathway
cell-cell signaling by wnt
chromatin binding
sequence-specific DNA binding
cell surface receptor signaling pathway involved in cell-cell signaling
cellular response to lipid
cellular response to organic cyclic compound
cellular response to hormone stimulus
intracellular membrane-bounded organelle
response to lipid
response to hormone
response to organic cyclic compound
cell-cell signaling
positive regulation of transcription by RNA polymerase II
cellular response to endogenous stimulus
response to endogenous stimulus
positive regulation of transcription, DNA-templated
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process